Frenz Biotech Pvt. Ltd.

OSTEON-CT

OSTEON-CT provides 100% RDA (Recommended Daily Allowance) of calcium carefully combined with co-factors, Calcitriol (active metabolite of Vitamin D), zinc and magnesium. Its play an important role in the health of the body – from the cardiovascular system to bone health and immune system strength.calcium supplement helps to correct low levels of calcium in the body when dietary intake is poor or the body requires higher than normal levels of calcium such as in pregnancy or while breast-feeding. It is also used in managing certain conditions such as osteomalacia, rickets, in the prevention and treatment of osteoporosis, malabsorption syndromes and as a phosphate binder in people who have high levels of phosphates in their blood and are undergoing kidney dialysis. Vitamin D is important for bone health since it aids calcium absorption in the gut. The nutrient also plays a role in the immune system and acts as an anti-inflammatory substance in the body. Magnesium may be one of the most important nutrients for overall health, since it is a cofactor in more than 300 enzyme systems in the body that regulate everything from protein synthesis to nerve and muscle function to blood pressure regulation. magnesium is also important for healthy teeth and bones and the function of key organs like the heart, liver and kidneys. While magnesium is found in foods like nuts, legumes and green leafy vegetables, many people don't get enough from their diet. According to the Institutes of Health, habitually low magnesium intake can increase the risk for cardiovascular disease, type-2 diabetes and migraine headaches. Another crucial mineral for health, zinc plays a role in immune system health, protein synthesis, DNA formation, cell division and healthy growth and development. Zinc has to be consumed every day because the body has no specialized zinc storage system, according to the National Institutes of Health. & UMMC, zinc also plays an important role in reproductive health, proper thyroid function, blood sugar regulation, prevention of age-related macular degeneration and protecting the body from free-radical damage.

For Doctors

Formulation

Each film coated tablet contains:

1250 mg calcium carbonate from an

inorganic sources of Oyster shell

eq. to elemental calcium…….500 mg

Calcitriol ………………………….0.25 mcg

Magnesium Hydroxide eq. to

El. Magnesium…………………….100 mg

Zinc Sulphate Monohydrate Eq. to

El Zinc…………………………………….7.5 mg

Mechanism of action

Absorption Calcium carbonate: About 15-25% gets absorbed in the GI tract. Converted to calcium chloride by gastric acid. Vitamin D well-absorbed in the GI tract in the presence of bile. Approximately 20 to 30% of dietary zinc is absorbed, primarily from the duodenum and ileum.

40% of magnesium intake absorbed in the small intestine, 5% absorbed in the large intestine and 55% leaving the body as waste

Distribution The vast majority of total body calcium (>99%) is present in the skeleton as calcium-phosphate complexes, primarily as hydroxyapatite. Vitamin D binds to receptors located throughout the body..Zinc is stored primarily in red and white blood cells, but also in the muscle, bone, skin, kidney, liver, pancreas, retina, and prostate. One half of body Mg is in bone, one-fourth is in muscle and one-fourth is in soft tissue. About 25% to 30% of total plasma Mg is bound to protein, 10% to 15% circulates in complex form and 55% to 60% is ionized

Excretion Calcium leaves body in faeces mainly. vitamin D and metabolites are mainly excreted in the bile and faeces. Zinc is widely distributed throughout the body and excreted mainly in the feces and only traces are found in the urine since kidney has little role in regulating body Zn content. Magnesium is excreted in urine.

Indication

During the active phase of growth and development of the skeleton

I.e. childhood, adolescence and early adulthood; pregnancy and lactation

Prevention and treatment of osteoporosis, particularly in women after menopause and elderly men;

Fractures and immobilization due to prolonged illness;

Long-term steroid therapy

Premenstrual syndrome

Dietary deficiencies i.e. malnutrition and weight-control dieting.

Treatment of hypocalcaemia – hyperparathyroidism, Osteomalacia (adults), rickets (infants, children), renal Osteodystrophy, chronic kidney disease

Dosages & Administration

Two Tablets per day with a main meal in divided dose. Swallow with water or a cold drink. Not to be chewed. Do not exceed the recommended intake. OSTEON-CT can be continued for as long as required.

Adverse Drug Reaction

OSTEON-CT is absolutely safe & side effects may rarely occur like Diarrhea nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, change in the amount of urine, bone/muscle pain, headache, increased thirst, increased urination, weakness, tiredness, fast/pounding heartbeat. It also may cause chills and fever, gastrointestinal distress, sore throat, ulcers or sores in the mouth or throat and fatigue and weakness. Calcitriol in OSTEON-CT -CT has a higher risk of inducing hypocalcaemia than Vitamin D. A very serious allergic reaction to this drug is rare. However give immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Drug Interaction

Calcium can decrease the absorption of other drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), bisphosphonates (e.g., alendronate), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin). Also, certain medications can decrease the absorption of vitamin D (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat). Therefore, separate your doses of these medications as far as possible from your doses of calcium/vitamin D. Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications. Vitamin D is very similar to calcitriol. Do not use medications containing calcitriol while using vitamin D.

Warning & Precaution

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products (such as calcitriol); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Avoid this medicine in high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart/blood vessel disease, kidney stones, kidney disease, certain immune system disorder (sarcoidosis), liver disease, certain bowel diseases (Crohn's disease, Whipple's disease), little or no stomach acid (achlorhydria), low levels of bile, untreated phosphate imbalance.This medication passes into breast milk. Consult your doctor before breast-feeding. Magnesium should be given very cautiously in the presence of serious impairment of renal function since it is excreted almost entirely by the kidneys.

Product Presentation

Tablet / 10’s / 90.00

For Patients

Why has OSTEON-CT been developed?: OSTEON-CT is scientifically formulated, and developed by experts, and each ingredient is included on the basis of research evidence. Bone is living tissue and to help keep it healthy, you must have the right nutrients in your daily diet. Calcium contributes to the maintenance of normal bone health, along with vitamin D which contributes to normal absorption and utilization of calcium in the body. Zinc and magnesium are also essential factors in helping to maintain normal bone health and unfortunately, many people, especially those cutting down on their dairy products, may not be getting all the calcium they need.
When is OSTEON-CT recommended?: Research shows the earlier both men and women receive a good supply of these nutrients the better. Getting enough calcium is especially important . But Now days because of life style and malabsorptions resulted in deficiency of calcium lead to may disorder

OSTEON-CT is formulated for long-term use and can be taken for as long as required, and is also approved by The Vegetarian Society.
What do I need to know before starting to use OSTEON-CT ?: OSTEON-CT is a calcium combination supplement, specially formulated as a daily nutritional safeguard for men and women of all ages especially for Old ages People and Kidney compromise people.
Can OSTEON-CT be used simultaneously with medications?: Generally, OSTEON-CT can be taken alongside medications because it contains only moderate levels of minerals and vitamin D. For specific advice on taking OSTEON-CT with medicines, we recommend that you contact your doctor or pharmacist first.
How and when should OSTEON-CT be used?: OSTEON-CT is available in tablet form. OSTEON-CT tablets - Two tablets daily (or one tablet twice daily) are recommended before or with meals, with water or a cold drink. Swallow without chewing. Always ensure that OSTEON-CT is taken with plenty of liquid to wash down the tablet. We do not recommend chewing the tablets because they have not been formulated as chewable preparations. Chewable tablets usually include flavorings, sweeteners and/or added ingredients to help break the tablet up in the mouth.
How many tablets does OSTEON-CT contain in pack ?: OSTEON-CT is available in 3*10 tablet packs. It is recommended to take two tablets per day.
Are there any undesired effects while taking OSTEON-CT?: OSTEON-CT has no known side effects when taken as directed. Do not exceed the recommended intake.
What are the active ingredients?: OSTEON-CT tablets contain the following active ingredients per two tablets: Calcium 500 mg; Magnesium 100 mg; Zinc 7.5 mg; and Calcitriol 0.25 mcg. OSTEON-CT tablets are safe.
For those people who experience difficulty swallowing tablets, are there any tips or recommendations to help ease swallowing OSTEON-CT tablets?: In general calcium supplement tablets do tend to be larger than other pharmaceutical preparations. The OSTEON-CT tablets have been specially designed with an oval, streamlined, Small than others preparation and easy to swallow shape.
What is the source of calcium used in OSTEON-CT ?: The calcium in OSTEON-CT is in the form of calcium carbonate, which provides the highest concentration of elemental calcium possible in a supplement. This means that OSTEON-CT can provide the full RDA of calcium and other minerals without the need to take lots of tablets. The calcium carbonate used is of high pharmaceutical grade from a natural source that is Oyster Shell.
Can calcium supplements like OSTEON-CT cause kidney stones?: It is important to select a calcium supplement which includes calcium in combination with other synergistic co-factors such as magnesium, as can be found in OSTEON-CT. The presence of the mineral magnesium, as well as contributing to the maintenance of normal bones, also contributes to normal protein synthesis and electrolyte balance.
Are OSTEON-CT tablets absorbed by the body as quickly as the liquid version?: OSTEON-CT tablets are tested to ensure the correct disintegration and dissolution profiles. Strict pharmaceutical disintegration tests, under the same comparative acidic conditions of the stomach, have shown the tablets to disintegrate between 6 to 15 mins (on average). Once the tablets have disintegrated the nutrients in tablet form will be absorbed at approximately the same rate as the liquid version.
Is OSTEON-CT recommended with any other product(s)?: OSTEON-CT has been carefully formulated so that it can be used in combination with any other formulation of vitamins & Minerals or other food supplements. However, for maximum results we recommend OSTEON-CT is taken at a separate time of the day, at least an hour apart from your main the effect of other products.
Difficulty swallowing tablets or capsules is fairly common - do you have any advice?: Difficulty in swallowing tablets is quite a common experience. We have researched OSTEON-CT extensively, tried different methods, by availing very small size of tablets among any other calcium preparation, but still we are giving some tips, which will help you swallow tablets with ease.

The usual advice for those who have difficulty in swallowing tablets, is to break the tablets into 2-3 pieces, before swallowing with plenty of liquid and in cases where people have more difficulty in swallowing tablets we recommend after chewing some food (e.g. banana), just before you swallow, pop the tablet into your mouth and swallow it together with the chewed food, followed by some liquid. The throat opens up wider automatically to swallow the chewed food and hence the tablet should go down with greater ease. Alternatively the tablets or capsules may be swallowed with thicker liquids such as yoghurts or smoothies. We hope these tips are of help.